Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.1
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
5
Total Fat
0.5 g
< 1%**
Vitamin A (from Retinyl Palmitate and Cod Liver Oil)
750 mcg
83%
Vitamin D3 (from Cholecalciferol and Cod Liver Oil)
6.75 mcg (270 IU)
34%
Cod Liver Oil
650 mg
†
Top Medical Research Studies
9.5
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Read More
8
We observed interesting effects when feeding cod liver oil to rats, particularly regarding blood clotting. The study aimed to determine how this treatment influences the production of certain compounds involved in thromboregulation, specifically thromboxane A2 (TxA2) and prostacyclin (PGI2).
What we found was that cod liver oil significantly lowered the levels of both TxA2 and PGI2, which are critical players in blood clotting. Notably, we did not detect any significant formation of other compounds like TxA3 and PGI3, often thought to have roles in managing clotting behaviors.
Interestingly, even with the reduced formation of these compounds, we noted a decrease in arterial thrombosis alongside a prolonged bleeding time. This indicates that while there may be some influence on blood clotting, the presence of the so-called “3-series” prostaglandins seems less critical than previously suggested.
Overall, this study reveals that cod liver oil does not enhance blood clot formation and suggests possible contradictions to previous beliefs about certain prostaglandins in clot regulation. Hence, it may not deliver the expected benefits in managing blood clotting effectively.
What we found was that cod liver oil significantly lowered the levels of both TxA2 and PGI2, which are critical players in blood clotting. Notably, we did not detect any significant formation of other compounds like TxA3 and PGI3, often thought to have roles in managing clotting behaviors.
Interestingly, even with the reduced formation of these compounds, we noted a decrease in arterial thrombosis alongside a prolonged bleeding time. This indicates that while there may be some influence on blood clotting, the presence of the so-called “3-series” prostaglandins seems less critical than previously suggested.
Overall, this study reveals that cod liver oil does not enhance blood clot formation and suggests possible contradictions to previous beliefs about certain prostaglandins in clot regulation. Hence, it may not deliver the expected benefits in managing blood clotting effectively.
Read More
8
We explored the connection between vitamin D levels and coronary thrombus load in patients who experienced ST-elevation myocardial infarction (STEMI). The study included 77 patients where we measured serum vitamin D levels, thrombus degree, and other relevant factors.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
Our findings revealed that a concerning 79.22% of participants showed vitamin D deficiency, with those having milder thrombus loads possessing significantly higher vitamin D levels compared to those with severe thrombus loads. Moreover, as we assessed the severity of coronary artery condition, we noted that patients with higher thrombus burden also had markedly greater scores of atherosclerosis.
Importantly, we found clear negative correlations between vitamin D levels and measures of thrombus burden. Lower vitamin D levels aligned with higher TIMI frame counts—meaning more extensive vascular obstruction—suggesting that vitamin D might play a role in blood clot formation.
Overall, we determined that low 25(OH)D3 levels could be an independent predictor of high coronary artery thrombus load in STEMI patients. These findings highlight the potential significance of monitoring and perhaps addressing vitamin D levels in this vulnerable group.
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Most Useful Reviews
7.5
Improved heart health
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
Read More
4
Decreased cholesterol levels
2 people found this helpful
Large jar of 250 capsules. This omega-3 is excellent quality. I take two capsules daily, which helps me feel better and has lowered my cholesterol levels. If heart problems or blood clots exist, you should aim for a daily intake of 3 grams of omega-3 (EPA and DHA combined). Be cautious about the content of omega-3 in each capsule before purchasing.
Read More
4
Lowered cholesterol levels
1 people found this helpful
One of my preferred omega-3 supplements, good quality. I consume six capsules daily, which has effectively improved my health and reduced my cholesterol levels. If there are heart issues or blood clots, it's advisable to take 3 grams of omega-3 per day, from the omega-3 fatty acids in fish oil. Always check the omega-3 content before buying.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.1
- All Researches
9.5
We investigated how a diet rich in cod liver oil affects blood clot formation by studying young pigs implanted with biodegradable polyurethane vascular prostheses. In this research, we used three groups of pigs: a control group, one group receiving a daily dose of aspirin, and another following a lipid-rich diet featuring cod liver oil. Over the course of the study, we noted the patency of vascular grafts at various intervals, particularly focusing on the impact of the lipid diet.
The results indicated promising findings for the pigs on the lipid diet. While the control group showed a 100% thrombosis rate, a remarkable 100% of the pigs receiving cod liver oil had patent grafts. Even at the final retrieval period, most of the pigs on the lipid-rich diet maintained a functioning graft, suggesting that cod liver oil may play a beneficial role in preventing blood clots. This effect could be linked to the diet’s ability to promote better endothelial growth within the graft.
Overall, the study points out that incorporating a lipid-rich diet, particularly with polyunsaturated fatty acids like those found in cod liver oil, may help enhance long-term success for vascular implants. It appears that this dietary strategy could improve outcomes by preventing blood clots and supporting the formation of new tissues in the vascular system.
The results indicated promising findings for the pigs on the lipid diet. While the control group showed a 100% thrombosis rate, a remarkable 100% of the pigs receiving cod liver oil had patent grafts. Even at the final retrieval period, most of the pigs on the lipid-rich diet maintained a functioning graft, suggesting that cod liver oil may play a beneficial role in preventing blood clots. This effect could be linked to the diet’s ability to promote better endothelial growth within the graft.
Overall, the study points out that incorporating a lipid-rich diet, particularly with polyunsaturated fatty acids like those found in cod liver oil, may help enhance long-term success for vascular implants. It appears that this dietary strategy could improve outcomes by preventing blood clots and supporting the formation of new tissues in the vascular system.
Read More
9.5
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Read More
9
Cod liver oil and thrombo-protection
We explored the effects of cod liver oil on blood clotting within the context of a broader dietary analysis. The study found that marine fish consumption decreases the likelihood of dying from ischemic heart disease. However, the use of fish oil as a supplement isn't universally recommended due to some potential issues. In high doses, fish oil can lower cholesterol and triglycerides but might also increase low-density lipoprotein (LDL) levels and raise the risks of free radical formation and bleeding.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
Read More
9
We explored the impact of adding fish oil, particularly cod liver oil, to a high-cholesterol diet on the formation of blood clots in swine. Our study involved swine fed a butter-cholesterol hyperlipidemic diet. We compared groups that received cod liver oil and menhaden oil with those that did not, keeping plasma cholesterol levels similar across all groups. This allowed us to focus specifically on how the fish oil might influence blood clot conditions.
One significant finding was the marked reduction in the number of platelet clumps, or microthrombi, in the swine that received fish oil. The treatment group showed a drop from nearly 1,000 platelet clumps per square millimeter to around 300 to 364, indicating that cod liver oil does indeed affect blood clot formation.
However, the most surprising result from our observation was that even with lower numbers of attached platelets and monocytes, the growth of atherosclerotic lesions—plaque buildup in arteries—was not significantly slowed in the fish oil groups. This contrasts with past studies where reducing plasma cholesterol resulted in a notable decrease in lesion growth.
Consequently, our research suggests that while cod liver oil may reduce certain aspects of blood clot formation, it does not significantly impact lesion development under the conditions we studied. This might imply that other factors, particularly plasma cholesterol levels, are critical in controlling lesion growth over the longer term.
One significant finding was the marked reduction in the number of platelet clumps, or microthrombi, in the swine that received fish oil. The treatment group showed a drop from nearly 1,000 platelet clumps per square millimeter to around 300 to 364, indicating that cod liver oil does indeed affect blood clot formation.
However, the most surprising result from our observation was that even with lower numbers of attached platelets and monocytes, the growth of atherosclerotic lesions—plaque buildup in arteries—was not significantly slowed in the fish oil groups. This contrasts with past studies where reducing plasma cholesterol resulted in a notable decrease in lesion growth.
Consequently, our research suggests that while cod liver oil may reduce certain aspects of blood clot formation, it does not significantly impact lesion development under the conditions we studied. This might imply that other factors, particularly plasma cholesterol levels, are critical in controlling lesion growth over the longer term.
Read More
9
We conducted research on the impact of cod liver oil (CLO) on blood clot formation in rats that were deficient in essential fatty acids (EFA). The study included diets with different types of oils, including sunflower seed oil (SO), which is rich in linoleic acid, and hydrogenated coconut oil (HCO), which does not contain EFAs.
Our findings revealed that both CLO and SO helped reverse the reduced ability of these EFA-deficient rats to form blood clots. Notably, the SO diet restored arachidonic acid levels in platelet phospholipids, which is essential for normal blood clotting. In contrast, while CLO did not influence arachidonic acid content, it significantly increased levels of other beneficial fatty acids—timnodonic acid (EPA) and cervonic acid (DHA).
Despite these positive changes, further research is necessary to determine if the alterations in fatty acid composition, particularly from CLO, are directly linked to the normalization of blood clot formation in these rats. We are particularly curious about the possible role of eicosanoids, compounds derived from fatty acids that might be influencing this process.
Our findings revealed that both CLO and SO helped reverse the reduced ability of these EFA-deficient rats to form blood clots. Notably, the SO diet restored arachidonic acid levels in platelet phospholipids, which is essential for normal blood clotting. In contrast, while CLO did not influence arachidonic acid content, it significantly increased levels of other beneficial fatty acids—timnodonic acid (EPA) and cervonic acid (DHA).
Despite these positive changes, further research is necessary to determine if the alterations in fatty acid composition, particularly from CLO, are directly linked to the normalization of blood clot formation in these rats. We are particularly curious about the possible role of eicosanoids, compounds derived from fatty acids that might be influencing this process.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved heart health
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
Read More
4
Decreased cholesterol levels
2 people found this helpful
Large jar of 250 capsules. This omega-3 is excellent quality. I take two capsules daily, which helps me feel better and has lowered my cholesterol levels. If heart problems or blood clots exist, you should aim for a daily intake of 3 grams of omega-3 (EPA and DHA combined). Be cautious about the content of omega-3 in each capsule before purchasing.
Read More
4
Lowered cholesterol levels
1 people found this helpful
One of my preferred omega-3 supplements, good quality. I consume six capsules daily, which has effectively improved my health and reduced my cholesterol levels. If there are heart issues or blood clots, it's advisable to take 3 grams of omega-3 per day, from the omega-3 fatty acids in fish oil. Always check the omega-3 content before buying.
Read More
Frequently Asked Questions
4
Decreased cholesterol levels
2 people found this helpful
Large jar of 250 capsules. This omega-3 is excellent quality. I take two capsules daily, which helps me feel better and has lowered my cholesterol levels. If heart problems or blood clots exist, you should aim for a daily intake of 3 grams of omega-3 (EPA and DHA combined). Be cautious about the content of omega-3 in each capsule before purchasing.
4
Lowered cholesterol levels
1 people found this helpful
One of my preferred omega-3 supplements, good quality. I consume six capsules daily, which has effectively improved my health and reduced my cholesterol levels. If there are heart issues or blood clots, it's advisable to take 3 grams of omega-3 per day, from the omega-3 fatty acids in fish oil. Always check the omega-3 content before buying.
7.5
Improved heart health
This omega improves blood vessel and heart health, effectively lowering cholesterol levels. The ingredients and quality are excellent.
9
We explored the impact of adding fish oil, particularly cod liver oil, to a high-cholesterol diet on the formation of blood clots in swine. Our study involved swine fed a butter-cholesterol hyperlipidemic diet. We compared groups that received cod liver oil and menhaden oil with those that did not, keeping plasma cholesterol levels similar across all groups. This allowed us to focus specifically on how the fish oil might influence blood clot conditions.
One significant finding was the marked reduction in the number of platelet clumps, or microthrombi, in the swine that received fish oil. The treatment group showed a drop from nearly 1,000 platelet clumps per square millimeter to around 300 to 364, indicating that cod liver oil does indeed affect blood clot formation.
However, the most surprising result from our observation was that even with lower numbers of attached platelets and monocytes, the growth of atherosclerotic lesions—plaque buildup in arteries—was not significantly slowed in the fish oil groups. This contrasts with past studies where reducing plasma cholesterol resulted in a notable decrease in lesion growth.
Consequently, our research suggests that while cod liver oil may reduce certain aspects of blood clot formation, it does not significantly impact lesion development under the conditions we studied. This might imply that other factors, particularly plasma cholesterol levels, are critical in controlling lesion growth over the longer term.
One significant finding was the marked reduction in the number of platelet clumps, or microthrombi, in the swine that received fish oil. The treatment group showed a drop from nearly 1,000 platelet clumps per square millimeter to around 300 to 364, indicating that cod liver oil does indeed affect blood clot formation.
However, the most surprising result from our observation was that even with lower numbers of attached platelets and monocytes, the growth of atherosclerotic lesions—plaque buildup in arteries—was not significantly slowed in the fish oil groups. This contrasts with past studies where reducing plasma cholesterol resulted in a notable decrease in lesion growth.
Consequently, our research suggests that while cod liver oil may reduce certain aspects of blood clot formation, it does not significantly impact lesion development under the conditions we studied. This might imply that other factors, particularly plasma cholesterol levels, are critical in controlling lesion growth over the longer term.
9.5
In a fascinating experiment involving young pigs, we observed how cod liver oil can prevent blood clotting in biodegradable vascular prostheses. The study included a total of 25 pigs, with 15 of them fed cod liver oil alongside their regular diets. They were compared against 10 control pigs that weren’t given any additional fatty acids.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
Over the course of several months, we performed imaging tests and found that all the control implants were completely thrombosed by day 30. In stark contrast, the pigs who received the cod liver oil showed 100% patency—or openness—of their grafts even at later stages of the study.
Upon retrieval, 7 out of 9 grafts in the cod liver oil group remained patent, indicating that the fish oil's rich content of n-3 polyunsaturated fatty acids could significantly modify lipid metabolism. This modification appears to prevent the clumping of platelets, which is a crucial factor in blood clot formation.
Tissue analysis revealed that the patent grafts were well-integrated with tissue resembling natural blood vessel lining, complete with muscle cells that indicate healthy growth. This study clearly shows that a diet enriched with essential fatty acids can play a substantial role in preventing thrombosis in biodegradable vascular prostheses. The combination of our innovative materials and dietary strategies could pave the way for better heart surgery outcomes in the future.
7
Cod liver oil's clotting effects
Our exploration looked into how cod liver oil affects blood clotting and its interaction with vascular health. We found that when blood vessels are damaged, platelet adhesion and coagulation are triggered, and thrombin plays a key role in the process of platelet aggregation.
The research highlighted that activated platelets encourage further coagulation, while prostaglandin I2 (PGI2) can actually inhibit this process when vascular tissue is damaged. Intriguingly, we observed that dietary cod liver oil could alter plasma coagulability, effectively reducing the procoagulation activity of vessel walls and lowering the risk of arterial thrombosis.
In contrast, another type of fish oil showed no significant impact on clotting related to vessel walls, indicating that the specific effects of cod liver oil are particularly noteworthy. Overall, it appears that cod liver oil may hold physiological significance in managing clot formation, especially in relation to primary hemostasis.
The research highlighted that activated platelets encourage further coagulation, while prostaglandin I2 (PGI2) can actually inhibit this process when vascular tissue is damaged. Intriguingly, we observed that dietary cod liver oil could alter plasma coagulability, effectively reducing the procoagulation activity of vessel walls and lowering the risk of arterial thrombosis.
In contrast, another type of fish oil showed no significant impact on clotting related to vessel walls, indicating that the specific effects of cod liver oil are particularly noteworthy. Overall, it appears that cod liver oil may hold physiological significance in managing clot formation, especially in relation to primary hemostasis.
9
Cod liver oil and thrombo-protection
We explored the effects of cod liver oil on blood clotting within the context of a broader dietary analysis. The study found that marine fish consumption decreases the likelihood of dying from ischemic heart disease. However, the use of fish oil as a supplement isn't universally recommended due to some potential issues. In high doses, fish oil can lower cholesterol and triglycerides but might also increase low-density lipoprotein (LDL) levels and raise the risks of free radical formation and bleeding.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
Our observations with swine indicated that when an atherogenic diet was supplemented with cod liver oil, there was a noticeable decrease in monocyte adhesion and platelet clumps on damaged coronary arteries, even when cholesterol levels were similar to the untreated group. This suggests that fish oil could have a thrombo-protective effect. We also conducted an in vitro assay to understand how fish oil seems to lessen these blood cell interactions.
In our tests, we found that eicosapentaenoic acid (EPA) was particularly effective in reducing the adhesion of human monocyte-like cells to endothelial cells stimulated by lipopolysaccharide (LPS). The improvements were noticeable only when EPA was administered soon after LPS stimulation. Furthermore, EPA exposure also lowered the expression of adhesion molecules on human umbilical vein endothelial cells. These findings imply that EPA could play a role in limiting the inflammation-related mechanisms associated with blood clotting.
References
- Kim DN, Eastman A, Baker JE, Mastrangelo A, Sethi S, et al. Fish oil, atherogenesis, and thrombogenesis. Ann N Y Acad Sci. 1995;748:474.
- Kim DN, Schmee J, Baker JE, Lunden GM, Sheehan CE, et al. Dietary fish oil reduces microthrombi over atherosclerotic lesions in hyperlipidemic swine even in the absence of plasma cholesterol reduction. Exp Mol Pathol. 1993;59:122.
- Galletti G, Gogolewski S, Ussia G, Farruggia F. Long-term patency of regenerated neoaortic wall following the implant of a fully biodegradable polyurethane prosthesis: experimental lipid diet model in pigs. Ann Vasc Surg. 1989;3:236.
- Hornstra G, Haddeman E, Don JA. Normalization by dietary cod-liver oil of reduced thrombogenesis in essential fatty acid deficient rats. Thromb Res. 1989;53:45.
- Galletti G, Ussia G, Farruggia F, Baccarini E, Biagi G, et al. Prevention of platelet aggregation by dietary polyunsaturated fatty acids in the biodegradable polyurethane vascular prosthesis: an experimental model in pigs. Ital J Surg Sci. 1989;19:121.
- Hansen JB, Olsen JO, Wilsgård L, Osterud B. Effects of dietary supplementation with cod liver oil on monocyte thromboplastin synthesis, coagulation and fibrinolysis. J Intern Med Suppl. 1989;731:133.
- Simonsen T, Nordøy A, Sjunneskog C, Lyngmo V. The effect of cod liver oil in two populations with low and high intake of dietary fish. Acta Med Scand. 1988;223:491.
- Nordøy A, Lagarde M, Renaud S. Platelets during alimentary hyperlipaemia induced by cream and cod liver oil. Eur J Clin Invest. 1984;14:339.
- Stoffersen E, Jørgensen KA, Dyerberg J. Antithrombin III and dietary intake of polyunsaturated fatty acids. Scand J Clin Lab Invest. 1982;42:83.
- Hornstra G. Platelet - vessel wall interaction: role of blood clotting. Philos Trans R Soc Lond B Biol Sci. 1981;294:355.
- Hornstra G, Christ-Hazelhof E, Haddeman E, ten Hoor F, Nugteren DH. Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3. Prostaglandins. 1981;21:727.
- Wang R, Tian Z, Wang C, Zhang B, Zhu M, et al. 1,25-Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS-CoV-2 spike protein via inhibiting integrin αIIbβ3 outside-in signaling. Cell Biochem Funct. 2024;42:e4039. 10.1002/cbf.4039
- Uguz B, Oztas S, Zengin I, Topal D, Tiryakioglu SK, et al. Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction. Eur Rev Med Pharmacol Sci. 2022;26:7015. 10.26355/eurrev_202210_29885
- Hejazi ME, Modarresi-Ghazani F, Hamishehkar H, Mesgari-Abbasi M, Dousti S, et al. The Effect of Treatment of Vitamin D Deficiency on the Level of P-Selectin and hs-CRP in Patients With Thromboembolism: A Pilot Randomized Clinical Trial. J Clin Pharmacol. 2017;57:40. 10.1002/jcph.774
- Blondon M, Rodabough RJ, Budrys N, Johnson KC, Berger JS, et al. The effect of calcium plus vitamin D supplementation on the risk of venous thromboembolism. From the Women's Health Initiative Randomized Controlled Trial. Thromb Haemost. 2015;113:999. 10.1160/TH14-05-0478
- Gholami K, Talasaz AH, Entezari-Maleki T, Salarifar M, Hadjibabaie M, et al. The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and hs-CRP Level in Patients With Venous Thromboembolism: A Randomized Clinical Trial. Clin Appl Thromb Hemost. 2016;22:483. 10.1177/1076029614568715
- Borst O, Münzer P, Schmid E, Schmidt EM, Russo A, et al. 1,25(OH)2 vitamin D3-dependent inhibition of platelet Ca2+ signaling and thrombus formation in klotho-deficient mice. FASEB J. 2014;28:2108. 10.1096/fj.13-239277
- Moscarelli L, Zanazzi M, Bertoni E, Caroti L, Rosso G, et al. Renin angiotensin system blockade and activated vitamin D as a means of preventing deep vein thrombosis in renal transplant recipients. Clin Nephrol. 2011;75:440.
- Jorde R, Sneve M, Torjesen P, Figenschau Y, Hansen JB. Parameters of the thrombogram are associated with serum 25-hydroxyvitamin D levels at baseline, but not affected during supplementation with vitamin D. Thromb Res. 2010;125:e210. 10.1016/j.thromres.2009.12.011
- Wu-Wong JR. Are vitamin D receptor activators useful for the treatment of thrombosis?. Curr Opin Investig Drugs. 2009;10:919.
